Related Experiment Video
Updated: Apr 23, 2026

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
Published on: September 2, 2020
Targeting TRPV3 for the Development of Novel Analgesics
Susan M Huang1, Man-Kyo Chung2
1Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA.
Transient Receptor Potential Vanilloid 3 (TRPV3) channels, similar to TRPV1, are involved in sensing temperature and pain. Research explores TRPV3
Area of Science:
- Neuroscience
- Molecular Biology
- Pharmacology
Background:
- Transient Receptor Potential Vanilloid 1 (TRPV1) is crucial for thermosensation and pain.
- TRPV1 antagonists have been pursued for pain management.
- The TRPV family includes other channels like TRPV3, sharing homology with TRPV1.
Purpose of the Study:
- To review the current understanding of TRPV3 channel biology, activation, and sensitization.
- To explore the consequences of TRPV3 manipulation on thermosensation and nociception.
- To assess the potential of TRPV3 modulators as analgesics.
Main Methods:
- Literature review of TRPV3 channel physiology, expression, and function.
- Analysis of evidence regarding TRPV3's role in thermosensation and nociception.
- Evaluation of TRPV3's homology and distinct features compared to TRPV1.
Main Results:
- TRPV3 shares approximately 40% homology with TRPV1.
- TRPV3 has distinct features in channel physiology, expression, and function compared to TRPV1.
- TRPV3 is expressed in the skin, suggesting a role in cutaneous sensation.
Conclusions:
- Understanding TRPV3 biology is essential for exploring its therapeutic potential.
- TRPV3 manipulation may offer novel analgesic strategies.
- Further research into TRPV3's role in thermosensation and nociception is warranted for drug development.
More Related Videos
09:39Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
12:09Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
Related Concept Videos
Analgesia and Pain Management
Thermosensation
Nociception