Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

1.1K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.1K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K
Inflammatory Response01:28

Inflammatory Response

12.3K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
12.3K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

1.4K
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
1.4K
Understanding Sleep01:11

Understanding Sleep

1.7K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.7K
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

7
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
7

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Insomnia and inflammatory exposure impair spatial memory and cognitive mapping in older adults: a randomized controlled trial.

Brain, behavior, and immunity·2026
Same author

A longitudinal analysis of bidirectional relationships between executive functioning and peripheral inflammation in schizophrenia.

Brain, behavior, and immunity·2026
Same author

Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial.

BMJ (Clinical research ed.)·2025
Same author

Inflammation-induced depressed mood and reward responsivity as a function of age in female adults: a randomized controlled trial of endotoxin.

Translational psychiatry·2025
Same author

Consummatory deficits in close social reward predict inflammation-induced depressed mood.

Psychoneuroendocrinology·2025
Same author

Interleukin-6 and tumor necrosis factor alpha as predictive biomarkers for depression and mania in young adults with depressive and bipolar disorder.

Journal of psychiatric research·2025

Related Experiment Video

Updated: Apr 23, 2026

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.9K

Sleep and inflammation in resilient aging.

Michael R Irwin1

  • 1Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience , University of California , Los Angeles, CA , USA ; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine , University of California , Los Angeles, CA , USA.

Interface Focus
|October 7, 2014
PubMed
Summary

Good sleep quality is crucial for healthy aging, impacting mental and physical health. This review explores how inflammation links sleep disturbances to increased risks of depression, pain, and chronic diseases in older adults.

Keywords:
agingdepressioninflammationmortalityresilience painsleep

More Related Videos

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.3K
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

19.7K

Related Experiment Videos

Last Updated: Apr 23, 2026

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.9K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.3K
A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

19.7K

Area of Science:

  • Gerontology
  • Sleep Medicine
  • Immunology

Background:

  • Sleep quality is vital for health and successful aging.
  • Inflammation is a key biological pathway linking sleep to health outcomes.
  • Aging is associated with changes in sleep patterns and increased inflammatory processes.

Purpose of the Study:

  • To review the relationship between sleep, inflammation, and health in aging.
  • To examine the role of inflammation in mediating sleep's effects on mental and physical health.
  • To discuss interventions targeting sleep to reduce inflammation and improve aging health.

Main Methods:

  • Literature review synthesizing current research on sleep, inflammation, and aging.
  • Analysis of biological mechanisms connecting sleep regulation and inflammatory pathways.
  • Exploration of potential therapeutic strategies.

Main Results:

  • Sleep disturbances are associated with elevated inflammation.
  • Inflammation mediates the impact of poor sleep on depression, pain, and chronic disease risk in aging.
  • Sleep interventions may offer a pathway to mitigate inflammation and enhance health.

Conclusions:

  • Sleep quality significantly influences health and resilience during aging.
  • Targeting sleep may be a viable strategy to manage inflammation and promote healthy aging.
  • Further research into sleep-based interventions for inflammation is warranted.