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Association between individual PM2.5 exposure and DNA damage in traffic policemen
Pengkun Li1, Jinzhuo Zhao, Changyi Gong
1From the Department of Environmental Health (Drs Li, Zhao, and Kan, and Mr Gong, Mr Bo, and Mr Song), School of Public Health, Fudan University; Department of Environment and Occupational Health (Dr Li), Shanghai Huangpu Centers for Disease Control and Prevention; and Department of Cardiology (Dr Xie), Xinhua Hospital, Shanghai Jiao Tong University, School of Medicine, China.
Objective:
The aim of this study was to explore the association between individual PM2.5 and DNA damage in traffic policemen.
Methods:
The participants included 110 traffic policemen and 101 common populations. The continuous 24-hour individual PM2.5 measurement was performed in participants. BPDE (benzo[a]pyrene 7,8-diol-9,10-epoxide)-DNA adducts and 1-OHP were detected.
Results:
The average concentration of 24-hour personal PM2.5 for traffic policemen was significantly higher than that in the control group. PM2.5 exposure is associated with a 1.1% increase in 1-OHP and 0.8% increase in BPDE-DNA adducts after adjusted for body mass index, educational time period, and alcohol intake. Exposure group has 2.04 times higher of 1-OHP and 1.25 times higher of BPDE-DNA adducts when compared to the control group.
Conclusions:
These results demonstrated that traffic policemen have been a high-risk group suffering DNA damage because of the high PM2.5 exposure.
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