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Updated: Apr 23, 2026

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
Bridging innate with adaptive immunity in transplantation: triggers, sensors, and modulators
Kathryn J Wood1, Christophe Mariat, Oliver Thaunat
11 Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK. 2 Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, France. 3 Department of Renal Transplantation and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France. 4 Department of Nephrology and Transplantation, University Hospital, Dijon, France. 5 Address correspondence to: Kathryn J. Wood, Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Abstract:
The molecular entities present on a cell or organ transplant that trigger the innate immune response and link to the adaptive immune system are increasingly recognized as a key influence on early graft function and for determining the microenvironment that will guide longer-term graft outcomes. The 2014 Beaune Seminar in Transplant Research discussed the evidence for triggers, sensors, and modulators of innate and adaptive immunity in response to alloantigens, challenged the conventional view, developed novel hypotheses, and highlighted the potential for therapeutic manipulation of these responses.
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