Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

398
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
398
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

924
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
924
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

394
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
394
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

998
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
998
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

542
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
542
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

251
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
251

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do 'leaders' in change sound different from 'laggers'? The perceptual similarity of New Zealand English voices.

PloS one·2025
Same author

Intraspeaker Priming across the New Zealand English Short Front Vowel Shift.

Language and speech·2021
Same author

Draft genome of the herbaceous bamboo Raddia distichophylla.

G3 (Bethesda, Md.)·2021
Same author

Topological Data Analysis as a Morphometric Method: Using Persistent Homology to Demarcate a Leaf Morphospace.

Frontiers in plant science·2018
Same author

Priming as a Motivating Factor in Sociophonetic Variation and Change.

Topics in cognitive science·2018
Same author

Incidence, correlates, and interventions used for pressure ulcers of the ear.

Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses·2011

Related Experiment Video

Updated: Apr 23, 2026

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.2K

Pediatric migraine: common, yet treatable.

Alicia Harding1, Lynn Clark

  • 1Alicia Harding is a nurse practitioner at Children's Medical Center, Dallas, Tex. Lynn Clark is a nurse practitioner, Manager Pain Management and Palliative Care at Children's Medical Center, Dallas, Tex.

The Nurse Practitioner
|October 7, 2014
PubMed
Summary

Pediatric migraine is a common and debilitating condition in children and adolescents. Improved recognition and management in primary care are needed due to knowledge gaps and treatment reluctance.

More Related Videos

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

19.1K
Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

17.2K

Related Experiment Videos

Last Updated: Apr 23, 2026

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders
05:49

Author Spotlight: Deciphering Electrical Networks Behind Complex Brain Activities and Disorders

Published on: November 1, 2024

1.2K
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

19.1K
Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

17.2K

Area of Science:

  • Neurology
  • Pediatrics
  • Headache Medicine

Background:

  • Migraine is a prevalent neurological disorder affecting children and adolescents.
  • It is increasingly recognized as a significant and debilitating condition in pediatric populations.
  • Current management in primary care settings requires improvement.

Purpose of the Study:

  • To highlight the need for enhanced recognition and management of pediatric migraine.
  • To address the knowledge gap concerning the unique features of migraine in children and adolescents.
  • To overcome the reluctance in treating this population.

Main Methods:

  • This study is a review and synthesis of current literature on pediatric migraine.
  • It analyzes the challenges in diagnosis and treatment within primary care.
  • Expert opinion and clinical guidelines are considered.

Main Results:

  • Pediatric migraine presents unique characteristics compared to adult migraine.
  • Primary care physicians often face challenges in diagnosing and managing migraine in children.
  • There is a documented reluctance among some healthcare providers to initiate treatment.

Conclusions:

  • Improved educational resources are essential for primary care providers.
  • Standardized diagnostic and treatment protocols for pediatric migraine should be developed.
  • Early and effective management can significantly improve outcomes for affected children and adolescents.