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Updated: Apr 23, 2026
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
[FLT3 mutation in acute promyelocytic leukemia patients with extramedullary relapse]
Objective:
To evaluate the role of FLT3 gene mutation in acute promyelocytic leukemia (APL) patients with extramedullary relapse.
Methods:
The blood and bone marrow samples were collected from 2 APL patients with extramedullary relapse and FLT3 gene mutation was detected with these samples. The correlation between FLT3 gene mutation and extramedullary relapse was analyzed.
Results:
A rare point mutation Asn841Gly (A841G) of FLT3-TKD and a novel mutation (c. 1209_1210insT/p. K404X) of WT1 were detected in a APL patient who suffered CNS relapse, while a rare point mutation Asp839Gly (D839G) of FLT3-TKD and a novel mutation Arg458Pro (c. 1373G>C) of WT1 were found in another APL patient who suffered testicular relapse.
Conclusion:
The rare point mutation of FLT3 as well as the novel mutation of WT1 were found in APL with extramedullary relapse.
