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Updated: Apr 23, 2026

Capturing Actively Produced Microbial Volatile Organic Compounds from Human-Associated Samples with Vacuum-Assisted Sorbent Extraction

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Aptamer-based-sorbents for sample treatment--a review.

Valérie Pichon¹, Fabien Brothier, Audrey Combès

¹Department of Analytical, Bioanalytical Sciences and Miniaturization (LSABM) - UMR CBI 8231 (CNRS-ESPCI), ESPCI ParisTech, PSL Research University, 10 rue Vauquelin, 75231, Paris Cedex 05, France, valerie.pichon@espci.fr.

Analytical and Bioanalytical Chemistry

|October 8, 2014

Summary

Oligosorbents, using aptamers for molecular recognition, offer highly selective sample pretreatment. This review details their development and application for extracting various targets from complex matrices.

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Area of Science:

Analytical Chemistry
Biotechnology
Materials Science

Background:

Selective sample pretreatment is crucial for accurate analysis.
Traditional methods like immunosorbents and molecularly imprinted polymers have limitations.
Aptamers offer high affinity and selectivity for target analytes.

Purpose of the Study:

To review the development and properties of aptamer-based sorbents (oligosorbents).
To discuss immobilization procedures and characterization of oligosorbents.
To highlight applications in selective extraction and sample purification.

Main Methods:

Immobilization of aptamers onto solid supports.
Characterization of aptamer-based extraction sorbents.
Evaluation of extraction recoveries, affinity, and analyte-aptamer interactions.

Main Results:

Oligosorbents demonstrate high selectivity and affinity for target analytes.
Extraction recoveries are closely related to immobilized aptamer quantity and affinity.
Matrix components and additives can affect performance and reusability.

Conclusions:

Aptamer-based sorbents are powerful tools for selective extraction and purification.
Oligosorbents show promise for analyzing complex samples like food, environmental, and biological fluids.
Further research can optimize oligosorbent stability and reusability for diverse analytical systems.