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Updated: Apr 23, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
New options for the adjuvant treatment of cutaneous melanoma?
Amy M Weise1, Lawrence E Flaherty
1Karmanos Cancer Institute, 4100 John R. Rd., Detroit, MI, USA, weisea@karmanos.org.
Abstract:
High-dose interferon is the current standard of care for the adjuvant treatment of high-risk cutaneous melanoma. Despite numerous clinical trials using interferon in a variety of doses and schedules, none have demonstrated a meaningful clinical improvement relative to standard high-dose interferon. Recently however, a phase III trial using biochemotherapy demonstrated a superior relapse-free survival benefit over standard interferon. In addition, several agents approved for use in metastatic melanoma are being investigated in the adjuvant setting.
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