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Modified cellulose nanocrystal for vitamin C delivery
Seyedeh Parinaz Akhlaghi1, Richard M Berry, Kam Chiu Tam
1Department of Chemical Engineering, Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada, spakhlag@uwaterloo.ca.
This study developed cellulose nanocrystal-chitosan oligosaccharide (CNC-CSOS) complexes to encapsulate vitamin C, enhancing its stability and antioxidant properties for cosmeceutical applications.
Area of Science:
- Materials Science
- Biochemistry
- Nanotechnology
Background:
- Vitamin C is a potent antioxidant with limited stability in formulations.
- Developing effective delivery systems is crucial for enhancing vitamin C's efficacy.
- Cellulose nanocrystals (CNC) and chitosan oligosaccharide (CSOS) offer biocompatible platforms for encapsulation.
Purpose of the Study:
- To create stable complexes of vitamin C (VC) using cellulose nanocrystal-chitosan oligosaccharide (CNC-CSOS).
- To evaluate the stability, antioxidant activity, and release profile of encapsulated vitamin C.
- To explore the potential of CNC-CSOS/VC complexes in cosmeceutical applications.
Main Methods:
- Ionic complexation of vitamin C with CNC-CSOS using tripolyphosphate.
- Characterization of complex formation using DSC, UV-vis spectrophotometry, and TEM.
- Assessment of encapsulation efficiency, in vitro release, and antioxidant activity.
- Isothermal titration calorimetry (ITC) to study interactions.
Main Results:
- High encapsulation efficiency of vitamin C (up to 91.0% at pH 5) was achieved.
- Complex formation was confirmed, with enhanced electrostatic interactions at pH 5.
- Sustained in vitro release of vitamin C for up to 20 days was observed.
- The CNC-CSOS/VC complexes exhibited superior stability and antioxidant activity compared to free vitamin C.
Conclusions:
- CNC-CSOS effectively encapsulates vitamin C, providing enhanced stability and sustained release.
- The developed complexes demonstrate significant antioxidant properties, superior to precursors.
- CNC-CSOS/VC complexes show promise for cosmeceutical topical formulations due to their dynamic antioxidant delivery.
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