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Transplantation: rituximab induction for prevention of HLA-antibody rebound

Puneet Sood1, Sundaram Hariharan1

  • 1Department of Medicine and Department of Transplant Surgery, University of Pittsburgh Medical Center, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA.

Nature Reviews. Nephrology
|October 8, 2014
PubMed

Desensitization therapy enables HLA-incompatible transplantation. However, desensitized patients have an increased risk of antibody-mediated rejection, and the presence of donor-specific antibodies (DSAs) is associated with poor outcomes. A new study has assessed the effect of rituximab induction on DSA production in kidney transplant recipients with high immunological risk.

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