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Proinflammatory cytokine levels in patients with conversion disorder
Utkan Tiyekli1, Okan Calıyurt1, Nimet Dilek Tiyekli2
11 Department of Psychiatry, Trakya University Hospital, Edirne, Turkey;
Stress impacts immune function in conversion disorder. Proinflammatory cytokine levels, specifically Tumour Necrosis Factor alpha (TNF-α), were altered during acute phases, suggesting diagnostic and therapeutic potential.
Area of Science:
- Psychoneuroimmunology
- Clinical Psychology
- Immunology
Background:
- Conversion disorder is a stress-regulated condition.
- Proinflammatory cytokines play a role in stress response and immune function.
Purpose of the Study:
- To investigate the relationship between proinflammatory cytokine levels and conversion disorder.
- To assess changes in cytokine levels during acute and post-acute phases of conversion disorder.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of Tumour Necrosis Factor alpha (TNF-α), Interleukin-1 beta (IL-1β), and Interleukin-6 (IL-6).
- Measurements were taken in 35 patients with conversion disorder and 30 healthy controls at baseline and during the acute phase of conversion disorder.
Main Results:
- Serum TNF-α levels were significantly decreased during the acute phase of conversion disorder and increased after the acute phase.
- No statistically significant differences were observed in serum IL-1β and IL-6 levels between patients and controls, or across different phases.
Conclusions:
- Acute stress in conversion disorder may lead to immune suppression, specifically affecting TNF-α.
- Monitoring TNF-α levels could offer diagnostic and therapeutic insights for conversion disorder.
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