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Implementation of a risk assessment program in a breast-imaging community practice
Stamatia Destounis1, Andrea Arieno2, Renee Morgan2
1Elizabeth Wende Breast Care, LLC., 170 Sawgrass Dr., Rochester, NY, 14620, USA. sdestounis@ewbc.com.
Breast Cancer (Tokyo, Japan)
|October 8, 2014
Summary
Implementing a breast cancer risk assessment program flagged 24,850 patients, identifying 40 BRCA mutations. Subsequent high-risk MRI screening detected 14 early-stage cancers, potentially improving patient outcomes.
Area of Science:
- Oncology
- Medical Genetics
- Radiology
Background:
- Community-based breast imaging practices can benefit from structured risk assessment programs.
- Early implementation of a risk assessment program was reviewed in an outpatient setting.
Purpose of the Study:
- To evaluate the initial results of a newly implemented breast cancer risk assessment program.
- To determine the yield of genetic mutations and cancer diagnoses in an at-risk patient population.
Main Methods:
- A health history form identified patients at increased risk for breast cancer.
- A radiology information system (RIS) flagged 25.7% of 96,389 patients for potential risk.
- Genetic counseling and testing (primarily BRCA1/BRCA2) were offered, followed by high-risk MRI screening.
Main Results:
- Out of 24,850 flagged patients, 887 underwent genetic testing, detecting 43 mutations (21 BRCA1, 19 BRCA2).
- 464 high-risk MRIs were performed, leading to 52 biopsies.
- 14 malignancies were diagnosed through MRI findings.
Conclusions:
- The risk assessment program successfully identified patients with BRCA1/BRCA2 mutations.
- Breast MRI screening in this at-risk cohort detected 14 cancers that might have otherwise been missed.
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