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Published on: March 10, 2026
Depression as first manifestation of a large intracerebral lymphoma
Thorleif Etgen1, Susanne Fleissner1
11 Department of Neurology, Kliniken Südostbayern - Klinikum Traunstein, Traunstein, Germany.
Objective:
The differentiation between a 'non-organic' depressive episode and an organic depressive disorder on the basis of clinical grounds might be challenging.
Methods:
We report a case with an initially typical severe depressive episode without any focal neurological deficits.
Results:
Only medical history from a third party raised doubts about this provisional diagnosis. Brain magnetic resonance imaging revealed a highly malignant diffuse large intracerebral B-cell lymphoma in the right frontal lobe changing the diagnosis into an organic depressive disorder. The patient recovered after neurosurgical resection, chemotherapy and autologous stem cell transplantation.
Conclusion:
This report helps to reduce possible errors in the differential diagnosis of depressive disorders by underlining the importance of a comprehensive medical history including anamnesis from a third party and neuroimaging, especially in first or atypical manifestation of depressive disorders.
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