Related Experiment Video
Updated: Apr 23, 2026
Dual-modality Molecular Cartography: Integrating Multiplex mRNA Detection with Protein Imaging Mass Cytometry
Published on: November 14, 2025
Molecular-genetic imaging of cancer
Il Minn1, Mitchell E Menezes2, Siddik Sarkar2
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland, USA.
Abstract:
Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization of various cellular processes including detection of cancer, and its attendant metastases. In recent years, significant effort has been expended in overcoming technical hurdles to enable clinical adoption of molecular-genetic imaging. This chapter will provide an introduction to the components of molecular-genetic imaging and recent advances on each component leading to safe, efficient clinical applications for detecting cancer. Combination with therapy, namely, generating molecular-genetic theranostic constructs, will provide further impetus for clinical translation of this promising technology.
Insights
Molecular-genetic imaging utilizes nonviral systems for safe, noninvasive cancer detection and metastasis visualization. Advances are paving the way for clinical use and combination with therapy for improved cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Medical Imaging
Background:
- Molecular-genetic imaging offers a noninvasive approach for visualizing cancer and metastases.
- Nonviral delivery systems are being developed for safer and more efficient molecular-genetic imaging applications.
- Clinical adoption of molecular-genetic imaging faces technical challenges that are being addressed.
Purpose of the Study:
- To introduce the components of molecular-genetic imaging.
- To review recent advances in molecular-genetic imaging for safe and efficient clinical applications.
- To discuss the potential of molecular-genetic theranostic constructs for clinical translation.
Main Methods:
- Review of current literature on molecular-genetic imaging components.
- Analysis of recent technological advancements in nonviral delivery systems.
- Exploration of theranostic construct development for combined imaging and therapy.
Main Results:
- Nonviral delivery systems show promise for safe and efficient molecular-genetic cancer imaging.
- Progress has been made in overcoming technical hurdles for clinical translation.
- Theranostic approaches integrating imaging and therapy are emerging.
Conclusions:
- Molecular-genetic imaging with nonviral systems is a promising tool for cancer detection and metastasis visualization.
- Continued advancements are crucial for the clinical adoption of this technology.
- The development of molecular-genetic theranostic constructs will accelerate clinical translation.
More Related Videos
06:54MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
Related Concept Videos
02:57Targeted Cancer Therapies
There are several types of targeted therapies against...
02:43Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...