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Related Experiment Video

Updated: Apr 23, 2026

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

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Altered cingulum bundle microstructure in autism spectrum disorder.

Stephanie H Ameis1, Jin Fan2, Conrad Rockel1

  • 11 Department of Psychiatry, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Acta Neuropsychiatrica
|October 8, 2014
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Summary
This summary is machine-generated.

Children with autism spectrum disorder (ASD) show immature white matter organization in the cingulum bundle. This brain connectivity difference, particularly in younger individuals, may impact socio-emotional development.

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Radiology

Background:

  • Autism spectrum disorder (ASD) is associated with altered white matter connectivity.
  • The cingulum bundle is a critical white matter tract for limbic system connectivity.

Purpose of the Study:

  • To investigate microstructural differences in the cingulum bundle using diffusion tensor imaging (DTI) in children and adolescents with ASD compared to controls.
  • To determine if these differences correlate with age and ASD diagnosis.

Main Methods:

  • Diffusion tensor imaging (DTI) tractography was used to analyze the cingulum bundle in 19 children/adolescents with ASD and 16 age-matched controls.
  • Key DTI metrics including fractional anisotropy (FA), mean, axial, and radial diffusivity were examined.

Main Results:

  • Significant age-by-group interactions were observed for all DTI metrics.
  • Younger ASD participants exhibited increased cingulum bundle diffusivity and decreased FA compared to controls.

Conclusions:

  • Findings suggest an immature microstructural organization of the cingulum bundle in young individuals with ASD.
  • This immaturity may affect limbic network synchronization and socio-emotional functioning in ASD.