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Hospitalizations and costs associated with hepatitis C and advanced liver disease continue to increase

Fujie Xu1, Xin Tong2, Andrew J Leidner3

  • 1Fujie Xu (fax1@cdc.gov) is a team leader in the Division of Viral Hepatitis, Centers for Disease Control and Prevention (CDC), in Atlanta, Georgia.

Health Affairs (Project Hope)
|October 8, 2014
PubMed

Insights

Hospitalizations for hepatitis C and advanced liver disease surged in the US from 2004-11. Increased morbidity and costs highlight hepatitis C as a growing public health concern requiring enhanced screening and treatment.

Area of Science:

  • Hepatology
  • Public Health
  • Epidemiology

Background:

  • Disease burden models predicted increasing hepatitis C-related liver disease morbidity in the US.
  • Hepatitis C virus (HCV) infection remains a significant global health challenge.
  • Advanced liver disease complications pose a substantial threat to patient health.

Purpose of the Study:

  • To analyze trends in hospitalizations for hepatitis C and associated advanced liver disease in the United States.
  • To quantify the rise in hospitalization rates and associated medical costs.
  • To assess the current public health impact of hepatitis C.

Main Methods:

  • Utilized data from the Nationwide Inpatient Sample (NIS) database for the period 2004-2011.
  • Analyzed hospitalization rates per 100,000 population for hepatitis C and advanced liver disease.
  • Calculated percentage increases in hospitalization rates for specific conditions like hepatorenal syndrome and portal hypertension.

Main Results:

  • Hepatitis C hospitalizations increased by 190% from 4.76 to 13.81 per 100,000 people (2004-05 to 2010-11).
  • Hospitalizations for advanced liver disease rose, with hepatorenal syndrome up 93% and portal hypertension up 62%.
  • In 2010-11, hepatitis C was the primary diagnosis for 64,867 hospitalizations, incurring $3.5 billion in charges.

Conclusions:

  • Hepatitis C is a growing public health problem in the US, characterized by increasing morbidity and medical costs.
  • Urgent implementation of recommended screenings (especially for those born 1945-65) and effective treatments is crucial.
  • Interventions have the potential to reverse the rising trends in hepatitis C-related liver disease.

Keywords:
Cost of Health CareHospitals

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