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Updated: Apr 22, 2026
Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection
Published on: May 9, 2022
Utility of the method using the tsukisui device to control intraoperative bleeding applied to neurofibroma resection
Taku Maeda1, Chu Kimura1, Kikuko Takahashi1
1Department of Plastic and Reconstructive Surgery, Hakodate General Central Hospital, Hakodate City, Hokkaido, Japan; and Department of Plastic and Reconstructive Surgery, Hokkaido University Graduate School of Medicine, Sapporo City, Hokkaido, Japan.
Summary:
The resection of neurofibromas in Von Recklinghausen's disease [neurofibromatosis type 1 (NF-1)] is frequently complicated due to size, location, hypervascularity, and tissue friability. A repeat resection, however, is necessary for patients with functional problems such as unexpected tumor bleeding or with changes in esthetic appearance. This report describes application of the method using the Tsukisui device to resecting NF-1 tumors while minimizing blood loss. The method using the Tsukisui device was applied for the resection of 8 NF-1 tumors (5 patients), and intraoperative blood loss, operative time, and postoperative complications were recorded. In all cases employing this method, intraoperative blood loss was <360 ml (10-360 ml), and none of the patients developed postoperative hematoma or other notable bleeding complications. The method using the Tsukisui device, which provided excellent hemostasis and was associated with few complications, shows promise for application to neurofibroma resection.
