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Methylprednisolone acetate-Eudragit® RS100 electrospuns: Preparation and physicochemical characterization
Nazila Jafari-Aghdam1,2, Khosro Adibkia1, Shahriar Payab1,2
1a Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.
Artificial Cells, Nanomedicine, and Biotechnology
|October 8, 2014
Summary
Electrospinning successfully created methylprednisolone acetate nanofibers and nanobeads. These formulations exhibited faster drug release via diffusion, indicating a promising, cost-effective fabrication method.
Area of Science:
- Materials Science
- Nanotechnology
- Pharmaceutical Sciences
Background:
- Developing advanced drug delivery systems is crucial for improving therapeutic efficacy.
- Electrospinning offers a versatile technique for fabricating nanomaterials for drug delivery applications.
Purpose of the Study:
- To formulate methylprednisolone acetate -Eudragit® RS100 nanofibers and nanobeads using electrospinning.
- To characterize the physicochemical properties and drug release kinetics of the electrospun formulations.
Main Methods:
- Electrospinning was employed to fabricate methylprednisolone acetate -Eudragit® RS100 nanofibers and nanobeads.
- Scanning electron microscopy (SEM) for morphology and particle size analysis.
- X-ray crystallography, differential scanning calorimetry (DSC), and FT-IR spectroscopy for physicochemical characterization.
- In vitro drug release studies and kinetic modeling (Weibull model).
Main Results:
- Electrospinning produced nanofibers and nanobeads with particle sizes ranging from 100 to 500 nm.
- Drug crystallinity decreased during electrospinning, with no observed drug-polymer interaction.
- Electrospun formulations demonstrated faster drug release compared to the pure drug, following a diffusion-controlled mechanism (Weibull shape factor < 0.75).
Conclusions:
- Electrospinning is a simple, cost-effective method for fabricating methylprednisolone acetate -Eudragit® RS100 nanofibers and nanobeads.
- The developed electrospun formulations show potential for enhanced drug delivery due to faster, diffusion-controlled release.
