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Absorption of amlodipine unaffected by food. Solid dose equivalent to solution dose
J K Faulkner1, M L Hayden, L F Chasseaud
1Department of Clinical Research, Pfizer Central Research, Sandwich, UK.
Arzneimittel-Forschung
|July 1, 1989
Summary
Amlodipine's oral bioavailability is consistent whether taken as a solution or capsule. Food intake does not affect amlodipine absorption rate or extent in healthy volunteers.
Area of Science:
- Pharmacokinetics
- Drug Absorption
- Clinical Pharmacology
Background:
- Amlodipine is a widely prescribed calcium channel blocker for hypertension and angina.
- Understanding amlodipine's oral bioavailability is crucial for optimizing therapeutic efficacy.
- Formulation and food intake can influence drug absorption profiles.
Purpose of the Study:
- To compare the oral bioavailability of amlodipine administered via solution versus capsule formulations.
- To evaluate the impact of fed versus fasting states on amlodipine's pharmacokinetic profile.
- To determine if amlodipine absorption is equivalent across different dosage forms and conditions.
Main Methods:
- Two separate pharmacokinetic studies were conducted in healthy volunteers.
- Amlodipine was administered as both a solution and a capsule.
- Subjects were assessed in both fed and fasting states for capsule administration.
Main Results:
- Oral bioavailability of amlodipine was equivalent between solution and capsule doses.
- No significant difference in the rate or extent of absorption was observed.
- Amlodipine bioavailability remained consistent in both fed and fasting states.
Conclusions:
- Amlodipine exhibits equivalent oral bioavailability regardless of formulation (solution vs. capsule).
- Food intake does not alter the pharmacokinetic profile of amlodipine.
- These findings support consistent therapeutic outcomes for amlodipine across different administration conditions.
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