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Updated: Apr 22, 2026

In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
Published on: November 28, 2017
A continuum of cells leading to an in-vivo humoral response
1Poultry Science Department, Mississippi State University and the Mississippi Agriculture and Forestry Experimental Station, Mississippi State, MS 39762, USA.
Abstract:
A fortuitous series of observations reported in 1955-56 allowed the first demonstration that a lymphoid structure, the bursa of Fabricius, exerts a profound influence on humoral immunity. These and later studies contributed to our understanding of the role of the cell in immunology and, in particular, to the T- and B-cell concept. The bursa gained acceptance as an exporter of specialized lymphocytes following the demonstration of certain bursa-dependent cell populations in specific regions of peripheral lymphoid tissue such as thegerminal centre. Here Bruce Glick and Imre Olah discuss a newly identified family of cells which they believe may influence B-cell differentiation.
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