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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Related Experiment Video

Updated: Apr 22, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model

Published on: April 13, 2015

Tumor-infiltrating leukocytes.

A Mantovani¹, R Evans²

¹Instituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy.

Immunology Today

|October 8, 2014

Summary

This summary is machine-generated.

Leukocytes are common in tumors. New methods allow researchers to analyze the tumor-host interaction by identifying these immune cells within neoplastic tissues.

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Area of Science:

Immunology
Oncology
Cell Biology

Background:

Leukocytes (white blood cells) are frequently observed within neoplastic (tumor) tissues.
Understanding the role of these immune cells is crucial for analyzing the tumor-host relationship.

Purpose of the Study:

To discuss current research on the analysis of leukocytes in neoplastic tissues.
To explore methods for identifying and separating leukocytes within the tumor microenvironment.

Main Methods:

Utilizing morphological analysis of leukocytes.
Employing histochemical staining techniques.
Applying monoclonal antibody-defined markers for cell identification.

Main Results:

Availability of advanced techniques for leukocyte separation in vitro.
Capability to identify leukocytes in situ within neoplastic tissues.
Enabling detailed analysis of the tumor-host interface.

Conclusions:

The development of advanced markers facilitates the study of leukocyte infiltration in tumors.
These methods enhance the understanding of the complex tumor-host interactions.
Further research is needed to fully elucidate the role of leukocytes in cancer progression.