On the necessity of the idiotype network: studies with nude mice

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H M Edinger1, C H Heusser

  • 1Basel Institute for Immunology (founded and supported by F. Hoffmann-La Roche and Co., Ltd, Basel, Switzerland) and Pharmaceutical Research Laboratories, Ciba-Geigy Ltd, Basel, Switzerland.

Immunology Today
|October 8, 2014
PubMed

jerne suggested that a quintessentialfeature of the immune system was the recognition of self-idiotypes(1,2). Despite intense interest and investigation, the concept remains a hypothesis. Here the authors discuss data which place in question the necessity of an idiotype network.

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