Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

4.7K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The contribution of «Télévie» and the «Léon Fredericq Foundation» to the fundamental cancer research in Liège].

Revue medicale de Liege·2021
Same author

[The Leon Fredericq Foundation against COVID-19 in Liege].

Revue medicale de Liege·2020
Same author

Histologic characterization of carotid plaques.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

[Cancer stem cells].

Bulletin et memoires de l'Academie royale de medecine de Belgique·2012
Same author

[Clinical case of the month. Intrapulmonary lung sequestration diagnosed in an adult].

Revue medicale de Liege·2011
Same author

[Fish and chips].

Revue medicale de Liege·2011
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

11.3K

Thymic lymphomas in the mouse.

R Hooghe1, J Boniver1

  • 1Department of Pathology, University of Liège at B-4000 Sart Tilman, Belgium; Department of Biology, Study Center for Nuclear Energy, B-2400 Mol, Belgium.

Immunology Today
|October 8, 2014
PubMed
Summary
This summary is machine-generated.

Basic information on T-cell lymphomas remains incomplete. This review explores whether T-cell tumors arise from a single cell type or various differentiation stages, crucial for understanding lymphoma and T-cell research.

More Related Videos

Intravital Imaging of the Mouse Thymus using 2-Photon Microscopy
10:08

Intravital Imaging of the Mouse Thymus using 2-Photon Microscopy

Published on: January 7, 2012

19.2K
A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice
07:17

A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice

Published on: August 23, 2022

2.5K

Related Experiment Videos

Last Updated: Apr 22, 2026

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

11.3K
Intravital Imaging of the Mouse Thymus using 2-Photon Microscopy
10:08

Intravital Imaging of the Mouse Thymus using 2-Photon Microscopy

Published on: January 7, 2012

19.2K
A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice
07:17

A Minimally Invasive, Accurate, and Efficient Technique for Intrathymic Injection in Mice

Published on: August 23, 2022

2.5K

Area of Science:

  • Immunology
  • Oncology
  • Molecular Biology

Background:

  • T-cell lymphomas are vital research tools but poorly understood.
  • Fundamental questions persist regarding their cellular origin and differentiation pathways.

Purpose of the Study:

  • To review the current understanding of T-cell lymphomas.
  • To discuss the elusive target cell for neoplastic transformation.
  • To explore recent molecular biology findings relevant to T-cell tumors.

Main Methods:

  • Review of existing literature.
  • Analysis of molecular biology studies.
  • Discussion of murine lymphoma models for human disease.

Main Results:

  • The cellular origin and differentiation potential of T-cell lymphomas are not fully elucidated.
  • Identifying the normal counterparts of tumor cells remains a challenge.
  • Molecular biology insights are beginning to shed light on these complex questions.

Conclusions:

  • Further research is needed to clarify the cellular origins of T-cell lymphomas.
  • Understanding these origins is critical for both immunological and oncological research.
  • T-cell lymphomas may represent a spectrum of diseases rather than a single entity.