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Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Related Experiment Video

Updated: Apr 22, 2026

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells

Published on: June 5, 2015

Immunoglobulin replacement therapy for primary immunodeficiencies.

Jonathan G Peter¹, Helen Chapel

¹Primary Immunodeficiency Unit, Level 7, Nuffield Department of Medicine, Oxford University Hospital, John Radcliffe Site, Headley Way, Oxford, OX3 9DU, UK.

|October 8, 2014

Summary

This summary is machine-generated.

Therapeutic human immunoglobulin therapy is a life-saving treatment for primary immunodeficiencies. This review covers immunoglobulin products, adverse reactions, and best practices for dosing and administration.

Keywords:

immunoglobulin replacement therapy intravenous immunoglobulin primary immunodeficiencies subcutaneous immunoglobulin

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Area of Science:

Immunology
Pharmacology

Background:

Exogenous antibody therapy, or therapeutic human immunoglobulin, has over a century of history.
It is a critical, life-long treatment for primary immunodeficiencies, particularly those with antibody failure.

Purpose of the Study:

To review current therapeutic human immunoglobulin products and their applications.
To provide evidence-based recommendations for clinical decision-making in immunoglobulin therapy.

Main Methods:

Literature review of current immunoglobulin products and adverse reactions.
Analysis of factors influencing successful immunoglobulin replacement therapy.
Synthesis of 'best practice' recommendations for dosing, administration, and patient management.

Main Results:

Description of available therapeutic human immunoglobulin products and common adverse reactions.
Identification of key factors for successful treatment, including product availability, immunodeficiency type, comorbidities, and multidisciplinary team involvement.
Evidence-based guidance on dosing, route of administration, and therapy location.

Conclusions:

Therapeutic human immunoglobulin is essential for patients with primary immunodeficiencies.
Optimal treatment requires careful consideration of product choice, administration route, patient factors, and ongoing clinical support.