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Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
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Cognitive control network function in alcohol use disorder before and during treatment with lorazepam
Claire E Wilcox1, Andrew R Mayer, Michael P Bogenschutz
11Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Substance Use & Misuse
|October 8, 2014
Summary
Individuals with alcohol use disorders (AUDs) show cognitive control deficits. Treatment with disulfiram and lorazepam did not normalize brain function or connectivity in the cognitive control network.
Area of Science:
- Neuroscience
- Psychiatry
- Addiction Medicine
Background:
- Alcohol use disorders (AUDs) are associated with cognitive control impairments.
- The impact of treatment on these cognitive deficits remains largely unknown.
- Anxiety often co-occurs with AUD, potentially influencing cognitive function.
Purpose of the Study:
- To investigate cognitive control network function and connectivity in individuals with AUD.
- To examine the effects of disulfiram plus lorazepam treatment on these neural measures.
- To compare brain function between AUD patients and healthy controls (HCs).
Main Methods:
- fMRI scans were conducted pre- and post-treatment on seven AUD patients (with anxiety) and nine HCs.
- A multisensory Stroop task assessed cognitive control during fMRI.
- Evoked BOLD signal and resting-state functional connectivity were analyzed.
Main Results:
- AUD patients exhibited hyperactivity in the cognitive control network compared to HCs.
- Altered functional connectivity within the cognitive control network was observed in AUD.
- Treatment with disulfiram plus lorazepam did not normalize brain activity or connectivity.
Conclusions:
- AUD is characterized by aberrant cognitive control network function and connectivity.
- Current treatment strategies may not fully restore neural mechanisms underlying cognitive control in AUD.
- Further research is needed to develop more effective interventions for cognitive deficits in AUD.
Keywords:
Stroopalcohol dependencealcohol use disorderbenzodiazepinecognitive controlconnectivityfMRIlorazepamtreatmentMore Related Videos
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