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Updated: Apr 22, 2026
The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
B-cell hyperactivity in murine lupus II. Defects in response to and production of accessory signals in lupus-prone
A N Theofilopoulos1, G J Prud'homme, T M Fieser
1Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA.
Abstract:
The first part of this discussion, published in last month's issue (p. 287), reviewed the immunological abnormalities observed in murine lupus. The current theories on the signal requirements for B cell activation, proliferation, and differentiation were also described. This month, the authors discuss recent experiments which suggest that the B cell hyperactivity associated with lupus may be the result of abnormal responses to and/or production of T-cell-derived B-cell-activating factors.
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