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High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

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Gut microbiota, host gene expression, and aging.

Paola Patrignani¹, Stefania Tacconelli, Annalisa Bruno

¹Department of Neuroscience and Imaging, Section of Cardiovascular and Pharmacological Sciences, Center of Excellence on Aging (CeSI), "G. d'Annunzio" University, Chieti, Italy.

Journal of Clinical Gastroenterology

|October 8, 2014

Summary

The gut microbiota influences host health and disease, interacting with host genetics and microRNAs (miRNAs). Advanced -omics approaches deepen understanding of these interactions for novel therapeutic strategies.

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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Area of Science:

Microbiology
Genetics
Molecular Biology

Background:

Gastrointestinal microbiota plays a crucial role in host physiology and disease, extending beyond the gut.
Host genetics interact with gut microbiota, influencing disease susceptibility.
Aging-associated oxidative stress can alter bacterial virulence, affecting host interactions.

Purpose of the Study:

To explore the complex interplay between host genetics, gut microbiota, and disease development.
To investigate the role of microRNAs (miRNAs) in mediating microbiota-host gene expression.
To highlight the potential of -omics approaches in advancing microbiota research.

Main Methods:

Review of current literature on host-microbiota interactions.
Discussion of the influence of host genetics and aging on gut microbiota.
Exploration of miRNA-mediated gene regulation by microbiota.

Main Results:

Gut microbiota and pathogens significantly impact host health and disease.
Host genetics and aging-induced oxidative stress modulate microbiota composition and virulence.
MicroRNAs are key regulators of gene expression influenced by microbiota.

Conclusions:

Understanding the gut microbiota's role is vital for disease prevention and treatment.
MicroRNA-mediated pathways offer novel therapeutic targets for microbiota-related diseases.
-Omics technologies promise to revolutionize our understanding of host-microbiota homeostasis.