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Updated: Apr 22, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Evolution of the lymphocyte
1Department of Biochemistry, Medical University of South Carolina, Charleston, SC 29403, U.S.A.
Abstract:
Invertebrates probably lack the cellular and molecular apparatus that characterizes vertebrate immunity but do have their own distinctive defense mechanisms (perhaps best termed 'quasi-immunity') worth investigation in their own right. Investigations of lymphocytes-like cells and immunity in animals near the transition point betweem invertebrates and vertebrates (e.g. the protochordates) may yet yield information on the early development of true vertebrate immunity. In this article Gregoru Warr discusses what light phylogenetic studies throw on the development of immunologically competent cells.
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