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Published on: November 29, 2024
Protein antigenicity: a static surface property
J Novotný1, M Handschumacher, R E Bruccoleri
1Molecular and Cellular Research Laboratory, Massachusetts General Hospital & Harvard Medical School, Boston, MA 02114, USA.
Much recent progress has been made in understanding the nature of antigenicity in the generation of antibodies. In this article Jiří Novotný and his colleagues discuss properties such as accessibility, flexibility and shape which determine the antigenicity of sites on proteins and consider the influence of these properties on the formation of immune complexes and the composition of the idiotype network.
Much recent progress has been made in understanding the nature of antigenicity in the generation of antibodies. In this article Jiří Novotný and his colleagues discuss properties such as accessibility, flexibility and shape which determine the antigenicity of sites on proteins and consider the influence of these properties on the formation of immune complexes and the composition of the idiotype network.
