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Related Concept Videos

Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Complementation Tests00:49

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A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
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Antimicrobial Proteins01:23

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Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
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Global Regulatory Systems01:28

Global Regulatory Systems

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Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
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Complementary DNA01:44

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Related Experiment Video

Updated: Apr 22, 2026

Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways
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Functional Complementation Analysis FCA: A Laboratory Exercise Designed and Implemented to Supplement the Teaching of Biochemical Pathways

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The complement genes.

H R Colten1

  • 1Division of Cell Biology, Department of Medicine, Children's Hospital Medical Center and the Ina Sue Perlmutter Cystic Fibrosis Research Center, Boston, MA 02115, USA.

Immunology Today
|October 8, 2014
PubMed
Summary
This summary is machine-generated.

Researchers are investigating complement gene expression at the RNA and DNA levels. This study aims to understand the molecular basis of genetic variations and deficiencies in the complement system.

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Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Genomics

Background:

  • Genetic polymorphisms and complement deficiencies are recognized in humans and animals.
  • Understanding the complement system is crucial for human and animal health.

Purpose of the Study:

  • To explore the molecular basis of genetic variants and abnormalities in the complement system.
  • To advance the understanding of complement gene expression at the molecular level.

Main Methods:

  • Studying complement gene expression at the RNA level.
  • Investigating complement gene organization and control at the DNA level.

Main Results:

  • Progress is being made in understanding the molecular underpinnings of complement variants.
  • Insights into the structure, organization, and expression control of complement genes are emerging.

Conclusions:

  • Further research into complement gene expression at RNA and DNA levels is essential.
  • Understanding these molecular mechanisms will aid in addressing complement-related disorders.