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Cellular receptors for fragments of the third component of complement

D T Fearon1

  • 1Department of Medicine, Harvard Medical School, and Department of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Immunology Today
|October 8, 2014
PubMed

Insights

Cellular receptors like CR1, CR2, and CR3 bind complement C3 fragments, mediating biological effects. Molecular identification of these proteins accelerates understanding of their roles in immune reactions.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • The complement system plays a crucial role in biological processes.
  • Cellular receptors bind C3 fragments, mediating many complement system effects.
  • These receptors are found on various cell types, including lymphocytes and erythrocytes.

Purpose of the Study:

  • To review the roles of complement receptors (CR1, CR2, CR3) in immunological reactions.
  • To highlight the impact of molecular identification on understanding these receptors.

Main Methods:

  • Review of existing literature.
  • Focus on molecular identification of complement receptors.

Main Results:

  • Complement receptors CR1, CR2, and CR3 bind C3 fragments.
  • These receptors are expressed on lymphocytes, myelomonocytic cells, erythrocytes, and renal podocytes.
  • Molecular identification has significantly advanced the understanding of these proteins.

Conclusions:

  • The molecular identification of complement receptors has accelerated research into their functions.
  • Understanding CR1, CR2, and CR3 is key to comprehending immunological reactions mediated by the complement system.

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