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Transient post-partum thyroid dysfunction and postnatal depression.

B Harris1, H Fung, S Johns

  • 1University of Wales College of Medicine, Cardiff, U.K.

Journal of Affective Disorders
|November 1, 1989
PubMed
Summary
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Postnatal depression is linked to thyroid dysfunction, not just thyroid antibodies. Early detection of thyroid issues may help identify mothers at risk for postpartum depression.

Area of Science:

  • Endocrinology
  • Psychiatry
  • Obstetrics

Background:

  • Thyroid dysfunction is common in pregnancy and postpartum.
  • Postnatal depression affects a significant number of mothers.
  • The relationship between thyroid autoimmunity and mood disorders requires further investigation.

Purpose of the Study:

  • To investigate the association between thyroid autoantibodies and postnatal depression.
  • To explore the link between diagnosed postpartum thyroid dysfunction and maternal mood.

Main Methods:

  • A population study assessed 147 women (65 antibody-positive, 82 antibody-negative) for thyroid dysfunction and postnatal depression at 6-8 weeks postpartum.
  • Women were evaluated using DSM-III criteria for major depression and validated mood scales (Raskin, Edinburgh, Montgomery-Asberg).

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Main Results:

  • Twenty-two women (15%) met criteria for major depression.
  • Thyroid autoantibodies showed minimal association with depressed mood.
  • A significant association was found between postnatal depression and actual thyroid dysfunction, with higher incidence in depressed women (P<0.01 to P<0.1).
  • Three of eight mothers with thyroid dysfunction experienced major depression.

Conclusions:

  • Postnatal depression is more closely associated with diagnosed thyroid dysfunction than with the mere presence of thyroid autoantibodies.
  • Screening for thyroid dysfunction may be beneficial in identifying mothers at risk for postpartum depression.