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Updated: Apr 22, 2026

Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
[IgE-induced anaphylactic reaction after eating lamb meat]
Kasper Lorenz Johansen1, Kirsten Rasmussen
1Medicinsk Afdeling, Holbæk Sygehus, Smedelundsgade 60, 4300 Holbæk.
A severe, delayed allergy to red meat, specifically galactose-alpha-1,3-galactose (alpha-gal) syndrome, was diagnosed in a patient experiencing anaphylaxis. This condition presents diagnostic challenges due to its delayed onset after allergen exposure.
Area of Science:
- Immunology
- Allergology
- Gastroenterology
Background:
- Delayed hypersensitivity reactions to food allergens are increasingly recognized.
- Alpha-gal syndrome is an emerging allergic condition linked to tick bites.
Observation:
- A 54-year-old male experienced severe anaphylaxis after consuming chili con carne and lamb meat.
- Symptoms manifested hours after ingestion, posing a diagnostic dilemma.
Findings:
- Blood tests revealed highly elevated specific IgE antibodies against galactose-alpha-1,3-galactose (alpha-gal).
- The patient was diagnosed with alpha-gal syndrome, a delayed allergy to mammalian meat.
Implications:
- This case highlights the importance of considering alpha-gal syndrome in patients with unexplained delayed anaphylaxis.
- Early diagnosis and avoidance of alpha-gal containing foods are crucial for managing this condition.
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