Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inter-reader variability when applying the 2013 Fleischner guidelines for potential solitary subsolid lung nodules.

Alex Penn1, Mingming Ma2, Benjamin B Chou2

  • 1Department of Radiology, Santa Clara Valley Medical Center, San Jose, CA, USA alex3005@stanford.edu.

Acta Radiologica (Stockholm, Sweden : 1987)
|October 9, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

711
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
711

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and internal validation of a nomogram for predicting short-term functional improvement after pharmacological treatment in severe symptomatic lumbar disk herniation.

Frontiers in medicine·2026
Same author

Self-delivering THPC-modified cytochrome c induces cancer cell apoptosis.

Organic & biomolecular chemistry·2026
Same author

Association of high-intensity evening light exposure with risk of incident age-related macular degeneration, cataract, and glaucoma: a prospective cohort study of 82,826 participants.

GeroScience·2026
Same author

Treadmill exercise mediates the neuroprotective effect in post-stroke depression rats through the PGC-1α/FNDC5/irisin pathway.

Behavioural brain research·2026
Same author

Expanding the clinical and mutational spectrum of hereditary spastic paraplegia type 4 in a cohort of patients from central China.

Frontiers in genetics·2026
Same author

Alglucosidase alfa demonstrates effectiveness and safety in Chinese patients with late-onset Pompe disease: A multi-center prospective study.

Molecular genetics and metabolism·2026
Same journal

Radiomics based on MRI for preoperative prediction of the tumor budding grade in rectal cancer: a systematic review and meta-analysis.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

Improved pancreatic imaging with photon-counting CT: a retrospective comparison with conventional CT.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

The role of ultrasonography in diagnosing cystic adventitial disease.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

Exploring artificial intelligence in point-of-care and standard breast ultrasound: a paired reader study.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

Diagnostic performance of contrast-enhanced ultrasound for thyroid nodule characterization: a systematic review and meta-analysis.

Acta radiologica (Stockholm, Sweden : 1987)·2026
Same journal

Dynamic breast magnetic resonance imaging features and pathological correlation of patients diagnosed with breast cancer under the age of 40.

Acta radiologica (Stockholm, Sweden : 1987)·2026
See all related articles

Applying the 2013 Fleischner Society guidelines for subsolid pulmonary nodules shows moderate inter-reader variability. Disagreements on nodule criteria and solid component presence significantly impact management recommendations.

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Medical Imaging Analysis

Background:

  • The Fleischner Society released guidelines in 2013 for managing subsolid pulmonary nodules.
  • Inter-reader variability in applying these guidelines remains undefined, impacting clinical practice reproducibility.

Purpose of the Study:

  • To assess the inter-reader variability in applying the 2013 Fleischner Society guidelines for solitary subsolid pulmonary nodules.
  • Evaluate the consistency of radiologists in classifying and managing these nodules.

Main Methods:

  • Retrospective review of CT scans with ground-glass lesions.
  • Three radiologists assessed nodule criteria, solid component presence, and measured components.
  • Inter-reader variability for management recommendations was calculated using Fleiss' kappa.
Keywords:
CT – spiraldecision analysislungthorax

Related Experiment Videos

Main Results:

  • Moderate agreement (70.4%, kappa=0.56) was observed among three radiologists for management recommendations of 44 nodules.
  • Variability was significantly linked to disagreements on subsolid nodule criteria (P<0.01) and solid component presence (P=0.01).
  • Measurement variability did not significantly influence final management decisions.

Conclusions:

  • There is moderate inter-reader variability in applying the 2013 Fleischner Society guidelines for subsolid pulmonary nodules.
  • Key factors contributing to variability include defining subsolid nodule criteria and identifying solid components.
  • Despite variability, measurement consistency is less impactful on final management recommendations.