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Age-related changes in contact photosensitivity differ among mouse strains
W R Brown1, G M Shivji, R D Furukawa
1Department of Medicine (Division of Dermatology), University of Toronto, Ontario, Canada.
Mechanisms of Ageing and Development
|August 1, 1989
Summary
Mouse strain differences impact age-related contact photosensitivity to tetrachlorosalicylanilide (TCSA). Immune cell changes, specifically T-suppressor cells, influence these varied responses in aging mice.
Area of Science:
- Immunology
- Dermatology
- Gerontology
Background:
- Age-related changes in immune responses are well-documented.
- Contact photosensitivity, mediated by the immune system, can vary significantly.
- Understanding these variations is crucial for studying aging and immune function.
Purpose of the Study:
- To investigate age-related changes in contact photosensitivity to tetrachlorosalicylanilide (TCSA) across different mouse strains.
- To determine the role of cyclophosphamide-sensitive T-suppressor cells in these age-related alterations.
Main Methods:
- Mice of various strains were exposed to TCSA.
- Reactivity to TCSA was assessed at different ages.
- The effect of cyclophosphamide administration on TCSA reactivity was evaluated to assess T-suppressor cell function.
Main Results:
- Significant differences in age-related TCSA reactivity were observed among mouse strains.
- Some strains showed decreased reactivity with age, while others exhibited increased reactivity or a biphasic response.
- Cyclophosphamide-sensitive T-suppressor cells were implicated in the age-related decline of TCSA reactivity in specific strains (MRL/MpJ +/+, MRL/MpJ lpr/lpr, SJL/J), but not others.
Conclusions:
- Mouse strain background critically influences age-related changes in contact photosensitivity.
- The involvement of T-suppressor cells in modulating these age-related immune responses is strain-dependent.