Emerging drugs and vaccines for candidemia

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Brad Moriyama1, Lori A Gordon, Matthew McCarthy

  • 1Pharmacy Department, NIH Clinical Center, Bethesda, MD, USA.

Mycoses
|October 9, 2014
PubMed

Insights

New antifungal drugs are crucial for treating invasive candidiasis due to rising resistance. Several investigational agents show promise, but more data is needed to establish their role in combating Candida infections.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pharmacology

Background:

  • Invasive candidiasis, including candidemia, significantly contributes to patient morbidity and mortality.
  • Increasing antifungal resistance in Candida species necessitates the development of novel therapeutic agents.
  • The pipeline for new antifungal drug development faces challenges, underscoring the urgency for innovation.

Purpose of the Study:

  • To review currently available and investigational antifungal agents for invasive candidiasis.
  • To assess the potential of new compounds and vaccines in preventing and treating Candida infections.
  • To identify antifungal agents currently in clinical trials for candidemia and invasive candidiasis.

Main Methods:

  • Comprehensive literature searches of MEDLINE, EMBASE, Scopus, and Web of Science up to January 2014.
  • Inclusion of conference abstracts and bibliographies of relevant articles.
  • Searches of ClinicalTrials.gov for ongoing clinical trials related to Candida infections.

Main Results:

  • Currently available antifungal treatments for candidemia were summarized.
  • Investigational agents such as isavuconazole, albaconazole, SCY-078, VT-1161, and T-2307 are in clinical trials.
  • Vaccines for Candida infection prevention were also reviewed.

Conclusions:

  • Further clinical data is required to define the therapeutic roles of emerging antifungal agents.
  • Despite challenges in drug development, there is a critical need for new antifungals to manage invasive candidiasis.
  • Continued research and development are essential to address the threat of life-threatening fungal infections.
Keywords:
Antifungal agentsCandidaCandidemiainvestigationalvaccines

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