Related Experiment Video
Updated: Apr 22, 2026
09:32
Evaluation of Auditory Brainstem Response in Chicken Hatchlings
Published on: April 1, 2022
4.4K
Automated auditory brainstem response in preterm newborns with histological chorioamnionitis
Adriana L Smit1, Jasper V Been, Luc J I Zimmermann
1a Department of Otorhinolaryngology/Head and Neck Surgery , Maastricht University Medical Centre , Maastricht , The Netherlands .
Summary
Histological chorioamnionitis did not predict adverse neonatal hearing outcomes in very preterm infants. Complicated clinical courses, not placental inflammation, were key predictors of abnormal hearing screenings.
Area of Science:
- Neonatal Health
- Perinatal Medicine
- Auditory Neuroscience
Background:
- Histological chorioamnionitis is a placental inflammation.
- Its association with neonatal hearing is not well-established.
- Very preterm infants are at higher risk for hearing impairment.
Purpose of the Study:
- To determine if histological chorioamnionitis is linked to adverse neonatal hearing outcomes.
- To identify predictors of abnormal auditory brainstem response in very preterm newborns.
Main Methods:
- Two cohorts of very preterm newborns (gestational age ≤ 32.0 weeks) were analyzed.
- Placental histology was linked to automated auditory brainstem response (AABR) outcomes.
- Multivariable analyses identified significant predictors.
Main Results:
- Histological chorioamnionitis did not predict abnormal AABR, with or without fetal involvement.
- Significant predictors of abnormal AABR included lower birth weight, lower umbilical cord artery pH, and mechanical ventilation.
- Odds ratios and confidence intervals were reported for key findings.
Conclusions:
- Histological chorioamnionitis is not associated with adverse neonatal hearing outcomes in very preterm infants.
- Factors indicating a complicated neonatal clinical course are the primary predictors of abnormal hearing screening results.
