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Updated: Apr 22, 2026

Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
[Esophageal diseases: GERD, Barrett, achalasia and eosinophilic esophagitis]
Xavier Calvet1, Albert Villoria1
1Servicio de Aparato Digestivo, Hospital de Sabadell, Institut Universitari Parc Taulí, Sabadell, Barcelona, España; Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, España; CIBERehd, Instituto de Salud Carlos III, Madrid, España.
Abstract:
At Digestive Disease Week (DDW) 2014, developments in esophageal disease were presented. Highlights include: the usefulness of impedancemetry to diagnose reflux disease, or the effectiveness of PPIs for treating non-cardiac chest pain. Concerning Barrett's esophagus, its prevalence is identical in patients with and without reflux symptoms, Barrett segments less than 1cm probably do not require follow-up, and in older patients with long-segment Barrett, initial endoscopies overlooked up to 2% of significant lesions. Regarding achalasia, surgical myotomy is no more effective than endoscopic dilation and may even be less effective than peroral endoscopic myotomy (POEM). In terms of eosinophilic esophagitis, it is important to systematically take biopsies in patients with dysphagia so that cases of eosinophilic esophagitis are not overlooked. In addition, for this condition, routine endoscopic dilations not only do not seem useful in improving the course of the disease, but could also worsen the response to medical treatment.
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