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Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
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Interleukin-6, a reliable prognostic factor for ischemic stroke
Sheyda Shaafi1, Ehsan Sharifipour1, Rouhollah Rahmanifar1
1Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Iranian Journal of Neurology
|October 9, 2014
Summary
Elevated Interleukin-6 (IL-6) levels correlate with increased severity and poorer outcomes in acute ischemic stroke (IS) patients. This inflammatory marker aids in predicting stroke prognosis and infarction size.
Area of Science:
- Neurology
- Inflammation Research
- Biomarker Discovery
Background:
- Interleukin-6 (IL-6) is a key inflammatory mediator with elevated levels observed in ischemic stroke (IS) patients.
- The role of IL-6 in assessing the severity and prognosis of acute IS requires further elucidation.
Purpose of the Study:
- To evaluate Interleukin-6 (IL-6) as a potential inflammatory marker for stroke severity and prognosis in acute ischemic stroke (IS).
Main Methods:
- A cross-sectional descriptive study involving 45 patients with first-time acute ischemic stroke (IS).
- Stroke severity assessed using the National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) at multiple time points.
- Serum IL-6 levels measured via ELISA on days 1 and 5 post-stroke; brain MRI used to determine infarction size.
Main Results:
- A significant positive correlation was observed between IL-6 levels and NIHSS/mRS scores (P < 0.001, r = 0.6).
- IL-6 levels showed a significant correlation with brain infarction size on MRI (P < 0.001, r = 0.7).
- Overall mortality rate was 13.3% by Day 365.
Conclusions:
- Interleukin-6 (IL-6) plays a role in determining the severity of ischemic stroke (IS).
- IL-6 concentrations are indicative of clinical outcomes in patients with ischemic stroke (IS).
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