Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antifungal Agents

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Plant functional traits, but not soil abiotic properties, mediate the legacy effects of microplastics on plant community assembly.

Frontiers in plant science·2026

Same author

Fe<sup>II</sup>-MOFs Catalyze the High Selective Oxidation of Sulfides Induced by Visible Light.

Inorganic chemistry·2026

Same author

Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans.

Phytochemistry·2026

Same author

Anion-Guided Controlled Molecular Growth of Multi-Component Giant Mo Wheel Family for Enhanced Oxidation Catalysis.

Journal of the American Chemical Society·2026

Same author

Research progress in fluorescence sensors for the detection of Fe<sup>3+</sup>, Cr<sub>2</sub>O<sub>7</sub><sup>2-</sup> and nitrobenzene based on MOFs.

Dalton transactions (Cambridge, England : 2003)·2025

Same author

Hydroxylation of HPPD facilitates its PUB11-mediated ubiquitination and degradation in response to oxidative stress in Arabidopsis.

Plant communications·2025

Search research articles

Related Experiment Video

Updated: Apr 22, 2026

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Two new compounds from Ganoderma lucidum.

Xin-Fang Wang¹, Yong-Ming Yan, Xin-Long Wang

¹a College of Pharmacy, Ningxia Medical University , Yinchuan 750004 , China.

Journal of Asian Natural Products Research

|October 9, 2014

Summary

This summary is machine-generated.

Researchers isolated two new pairs of enantiomers, lucidulactones A and B, from Ganoderma lucidum. Spectroscopic methods and chiral High-Performance Liquid Chromatography (HPLC) were used to determine their structures and separate the antipodes.

Keywords:

Ganoderma lucidum enantiomers lactones

More Related Videos

Production and Testing of Moisture Behavior and Thermal Properties of Rapeseed Straw and Ganoderma resinaceum Mycelium Bio-Composites

Production and Testing of Moisture Behavior and Thermal Properties of Rapeseed Straw and Ganoderma resinaceum Mycelium Bio-Composites

Published on: September 5, 2025

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Published on: February 2, 2024

Related Experiment Videos

Last Updated: Apr 22, 2026

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

Production and Testing of Moisture Behavior and Thermal Properties of Rapeseed Straw and Ganoderma resinaceum Mycelium Bio-Composites

Production and Testing of Moisture Behavior and Thermal Properties of Rapeseed Straw and Ganoderma resinaceum Mycelium Bio-Composites

Published on: September 5, 2025

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Preparation of Gynura bicolor DC samples for High-Resolution Tandem Mass Spectrometry

Published on: February 2, 2024

Area of Science:

Natural Product Chemistry
Pharmacognosy
Organic Chemistry

Background:

Ganoderma lucidum is a medicinal mushroom with a history of traditional use.
The chemical constituents of Ganoderma lucidum are of interest for their potential biological activities.
Isolation and characterization of novel compounds contribute to understanding the mushroom's medicinal properties.

Purpose of the Study:

To isolate and characterize new chemical compounds from Ganoderma lucidum.
To determine the structures of the isolated compounds using spectroscopic techniques.
To separate and analyze the enantiomers of the newly discovered compounds.

Main Methods:

Extraction and isolation of compounds from Ganoderma lucidum.
Structure elucidation using Nuclear Magnetic Resonance (NMR) and Mass Spectrometry (MS).
Chiral High-Performance Liquid Chromatography (HPLC) for enantiomeric separation.

Main Results:

Two new pairs of enantiomers, lucidulactones A and B, were identified.
The structures of lucidulactones A and B were determined.
Separation of the (-) and (+) antipodes of the new compounds was achieved using chiral HPLC.

Conclusions:

The study successfully identified and characterized novel enantiomers from Ganoderma lucidum.
The findings expand the knowledge of Ganoderma lucidum's chemical diversity.
The methods employed provide a basis for further investigation of these compounds.