Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

121
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
121
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

74
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
74
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

182
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
182
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.0K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.0K
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

3
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
3
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

5.7K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A 53-year-old woman with necrotising myopathy presenting with cough and respiratory distress: a diagnostic conundrum.

Breathe (Sheffield, England)·2025
Same author

The Enigma of Migraine, Platelet Dysfunction, and White Matter Hyperintensities.

Annals of Indian Academy of Neurology·2024
Same author

Impact of JME on quality of life: Does a well-controlled epilepsy also hamper the psychological wellbeing?

Epilepsy research·2023
Same author

Evaluation of hand hygiene compliance over the years, in an intensive care unit of a north Delhi hospital preparing for accreditation: A 3-year study.

Journal of family medicine and primary care·2020
Same author

Idiopathic CD4 lymphocytopenia with sensorimotor polyneuropathy.

Annals of Indian Academy of Neurology·2016
Same author

Sepsis Associated Encephalopathy.

Advances in medicine·2015
Same journal

Relationship of serum nesfatin-1 levels with body mass index and c-reactive protein in patients presenting to the emergency department with epileptic seizures.

Postgraduate medicine·2026
Same journal

Clinical pharmacokinetics of colistimethate sodium and formed colistin in patients with renal impairment or on dialysis modalities: a systematic review and implications for precision dosing.

Postgraduate medicine·2026
Same journal

The role of type D personality in pregnancy symptom severity, functional limitations, and maternal ambivalence.

Postgraduate medicine·2026
Same journal

Operational and demographic predictors of leaving without being seen in a high-volume tertiary emergency department: a five-year case-control study.

Postgraduate medicine·2026
Same journal

Risk of adverse effects of the concomitant use of statins with calcium channel blockers: a systematic review and meta-analysis.

Postgraduate medicine·2026
Same journal

Association between frailty and major chronic disease-free life expectancy: a large community-based longitudinal study.

Postgraduate medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 22, 2026

Targeting Biofilm Associated Staphylococcus aureus Using Resazurin Based Drug-susceptibility Assay
10:00

Targeting Biofilm Associated Staphylococcus aureus Using Resazurin Based Drug-susceptibility Assay

Published on: May 5, 2016

12.8K

Staphylococcus aureus bacteremia: targeting the source.

Sharon Rainy Rongpharpi1, Shalini Duggal, Hitesh Kalita

  • 1Senior Resident, Department of Microbiology, Dr. Baba Saheb Ambedkar Hospital, New Delhi, India.

Postgraduate Medicine
|October 9, 2014
PubMed
Summary
This summary is machine-generated.

Staphylococcus aureus bacteremia causes significant illness and death in India. Identifying and treating infection sources is crucial to prevent recurring Staphylococcus aureus bacteremia and reduce mortality.

More Related Videos

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.2K
Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes
12:27

Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes

Published on: January 3, 2020

8.4K

Related Experiment Videos

Last Updated: Apr 22, 2026

Targeting Biofilm Associated Staphylococcus aureus Using Resazurin Based Drug-susceptibility Assay
10:00

Targeting Biofilm Associated Staphylococcus aureus Using Resazurin Based Drug-susceptibility Assay

Published on: May 5, 2016

12.8K
Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.2K
Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes
12:27

Quantifying the Cytotoxicity of Staphylococcus aureus Against Human Polymorphonuclear Leukocytes

Published on: January 3, 2020

8.4K

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Staphylococcus aureus bacteremia is a leading cause of mortality and morbidity in India.
  • Limited research exists on the specific sources of Staphylococcus aureus bacteremia in the Indian population.
  • Staphylococcus aureus possesses numerous virulence factors contributing to severe infections.

Purpose of the Study:

  • To review potential sources of Staphylococcus aureus bacteremia.
  • To emphasize the importance of identifying and eradicating infection origins.
  • To discuss the role of appropriate antibiotic therapy in preventing relapse and recurrence.

Main Methods:

  • Literature review of studies on Staphylococcus aureus bacteremia.
  • Analysis of virulence factors associated with Staphylococcus aureus infections.
  • Discussion of clinical management strategies for bacteremia.

Main Results:

  • Staphylococcus aureus employs various toxins and adhesins to cause diverse and serious infections.
  • Identifying the primary source of infection is critical for effective treatment.
  • Source control combined with targeted antibiotic therapy is essential for patient outcomes.

Conclusions:

  • Addressing the sources of Staphylococcus aureus bacteremia is vital for reducing its impact in India.
  • Comprehensive treatment plans must include source elimination and appropriate antibiotic regimens.
  • Further research is needed to elucidate common origins and improve management protocols.