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Intraocular pressure and associations in children. The Gobi Desert Children Eye Study

Da Yong Yang1, Kai Guo2, Yan Wang2

  • 1Southern Medical University, Guangzhou, Guangdong, China; Department of Ophthalmology, Guangdong General Hospital/Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

Plos One
|October 9, 2014
PubMed

Insights

This study found that higher intraocular pressure (IOP) in Gobi Desert children is linked to steeper corneal curvature, younger age, and higher blood pressure or cerebrospinal fluid pressure (CSFP). These factors may influence IOP measurements.

Area of Science:

  • Ophthalmology and Public Health
  • Pediatric Eye Health
  • Epidemiology

Background:

  • Intraocular pressure (IOP) is a critical factor in eye health, with potential links to conditions like glaucoma.
  • Understanding IOP variations in diverse populations, such as those in remote areas like the Gobi Desert, is important for comprehensive eye care.
  • Previous research suggests associations between IOP and various physiological parameters, but data in pediatric populations from unique geographic settings is limited.

Purpose of the Study:

  • To investigate the prevalence and determinants of intraocular pressure (IOP) among school-aged children residing in an oasis community within the Gobi Desert.
  • To explore the associations between IOP and other physiological measurements, including refractive error, blood pressure, and estimated cerebrospinal fluid pressure (CSFP).

Main Methods:

  • A cross-sectional, school-based study was conducted in the Ejina region, involving ophthalmic examinations and non-contact tonometry.
  • Measurements included intraocular pressure (IOP), blood pressure, body height, and weight for a cohort of 1565 children.
  • Multivariate analysis was employed to identify factors associated with higher IOP in both the right and left eyes.

Main Results:

  • Higher IOP in the right eye was significantly associated with younger age, elevated diastolic blood pressure, increased corneal refractive power, more myopic refractive error, and paternal Han Chinese ethnicity.
  • In adjusted models, higher IOP was also linked to elevated estimated cerebrospinal fluid pressure (CSFP), alongside corneal refractive power and paternal ethnicity.
  • Similar associations were observed for the left eye, including younger age, female gender, higher corneal refractive power, more myopic refractive error, and higher estimated CSFP.

Conclusions:

  • In school children from the Gobi Desert, elevated intraocular pressure (IOP) is associated with steeper corneal curvature, younger age, and higher blood pressure.
  • An alternative association suggests a link between higher IOP and elevated estimated cerebrospinal fluid pressure (CSFP), warranting further investigation.
  • The findings highlight the importance of considering corneal curvature in IOP measurement corrections and suggest potential links between IOP and CSFP in pediatric populations.
Abstract

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