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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Evolution of specificity in protein-protein interactions.

Orit Peleg1, Jeong-Mo Choi2, Eugene I Shakhnovich2

  • 1School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts.

Biophysical Journal
|October 9, 2014
PubMed
Summary

Protein evolution requires reduced structural stability, especially for single-interface hub proteins. Hydrophobic and electrostatic interactions drive protein-protein interaction network design in cellular environments.

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