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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Poly(ε-caprolactone) (PCL) is a biodegradable polymer with various applications.
  • Cyclodextrins (CDs) are known for their ability to form inclusion complexes and modify material properties.
  • Electrospinning is a versatile technique for producing polymer nanofibers.

Purpose of the Study:

  • To investigate the effects of alpha- and gamma-cyclodextrins (α- and γ-CDs) on the thermal and crystallization behavior of electrospun PCL nanofibers.
  • To explore the potential of PCL/CD composite nanofibers for medical applications.

Main Methods:

  • Electrospinning of PCL/CD mixtures.
  • Scanning electron microscopy (SEM) for morphology analysis.
  • Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and wide-angle X-ray diffraction (WAXD) for material characterization.
  • Differential scanning calorimetry (DSC) for thermal analysis.
  • Water contact angle (WCA) measurements for hydrophobicity assessment.
  • Phenolphthalein absorption tests for inclusion complex (IC) formation kinetics.

Main Results:

  • PCL/CD composite nanofibers were successfully fabricated for the first time.
  • Addition of CDs increased the diameter of PCL nanofibers.
  • DSC revealed enhanced PCL crystallization with increased CD loading, indicating nucleation effects.
  • WCA measurements showed decreased hydrophobicity with increasing CD concentration.
  • γ-CD functionalized nanowebs demonstrated superior performance in inclusion complex formation compared to α-CD.

Conclusions:

  • CDs act as effective nucleating agents for PCL crystallization in electrospun fibers.
  • PCL/CD composite fibers exhibit reduced hydrophobicity and enhanced encapsulation capabilities.
  • These modified nanofibers hold promise for applications in medical dressings, particularly for wound odor absorption due to the known ability of CDs to complex with odor molecules.