Classification and pathological characteristics of the cortical dysplasias

Focal cortical dysplasias (FCD) are a well-recognized cause of medically intractable epilepsy. They are defined as malformations of cortical development and are marked by abnormalities of cortical layering and neuronal differentiation and maturation. A number of classification approaches have been devised over the last four decades, indicating controversies surrounding issues of recognition, definition, and philosophical approach. More recent attempts have attempted to correlate morphologic phenotype with clinical or developmental parameters in order to provide a clinical relevance.

This short review provides an overview of the issues which account for the varied historical approaches to FCD classification and descriptions of gross pathologic findings associated with FCD and an overview of two more recently developed and widely used schema, the Palmini et al. (Neurology 62: S2-8, 2004) and the International League Against Epilepsy (ILAE) classifications Blumcke et al. Epilepsia 52: 158-174, 2011. The pathologic features of these two approaches will be reviewed and compared, including discussion of their limitations.