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[Alemtuzumab, a monoclonal antibody against CD52: hopes and fears]

Masahiro Mori1

  • 1Department of Neurology, Chiba University Graduate School of Medicine.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|October 10, 2014
PubMed

CD52, an antigen expressed on immune cells including mature T lymphocytes, is thought to be involved in immunomodulatory mechanisms. Alemtuzumab is a humanized monoclonal antibody against CD52, which causes a marked and long-term decrease in immune cells, especially CD4-positive T lymphocytes. A few randomized clinical trials have revealed the efficacy of alemtuzumab to be much greater than that of interferon-β in patients with relapsing-remitting multiple sclerosis. However, the development of other autoimmune disorders, including autoimmune thyroid disorders and thrombocytic purpura, because of alemtuzumab application has been considered an obstacle in its widespread use.

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