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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
Predictive factors analysis for malignant peritoneal mesothelioma
Shi Jin1, Shoubo Cao, Jingyan Cao
1Department of Medical Oncology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150081, China.
Background:
Malignant peritoneal mesothelioma (MPM) is an uncommon disease with a dismal prognosis and unclear natural history. The present study aims to assess potential prognostic factors and management of MPM.
Methods:
Clinical records of 39 patients with MPM between December 2003 and April 2014 were retrospectively reviewed. Overall survival was identified with Kaplan-Meier curves and Cox regression analysis.
Results:
Mean age of 39 patients was 55.0 years; asbestos exposure was recorded in two patients. Main presentations were abdominal distension, abdominal pain, and weight loss. Thrombocytosis, low serum albumin level, and anemia were principal laboratory abnormalities. Ascites, peritoneal cavity mass, and peritoneum thickening were the main signs on CT scans. Cytoreductive surgery (CRS) plus adjuvant therapies were performed in 22 patients, single chemotherapy in 13, and best supportive care in 4. Median survival time was 10.0 months after pathological diagnosis, with a 6-, 12-, 18-, and 24-month survival rate of 84.4, 31.6, 18.5, and 15.8 %, respectively. Significant prognostic factors were age, performance status (PS), abdominal pain, serum albumin level, thrombocytosis, and treatment strategy on univariate analysis, while only age, abdominal pain, and treatment strategy hold statistical significance on multivariate analysis.
Conclusions:
Age ≤65 years, abdominal pain, and CRS plus adjuvant therapy are independent positive prognostic factors of MPM.
Insights
Malignant peritoneal mesothelioma (MPM) survival is improved in patients aged ≤65 years with abdominal pain who receive cytoreductive surgery plus adjuvant therapy. These factors independently predict better outcomes for MPM patients.
Area of Science:
- Oncology
- Surgical Oncology
- Medical Oncology
Background:
- Malignant peritoneal mesothelioma (MPM) is a rare cancer with poor prognosis and poorly understood natural history.
- This study investigates prognostic factors and management strategies for MPM.
Purpose of the Study:
- To identify independent prognostic factors for malignant peritoneal mesothelioma (MPM).
- To evaluate the impact of treatment strategies on MPM patient survival.
Main Methods:
- Retrospective review of clinical records for 39 MPM patients (2003-2014).
- Overall survival analyzed using Kaplan-Meier curves and Cox regression.
- Prognostic factors assessed through univariate and multivariate analyses.
Main Results:
- Median survival was 10.0 months; 2-year survival rate was 15.8%.
- Key clinical presentations included abdominal distension, pain, and weight loss.
- Laboratory and CT scan findings indicated ascites, peritoneal masses, and thickening.
- Cytoreductive surgery (CRS) plus adjuvant therapy was associated with improved survival compared to chemotherapy or best supportive care.
Conclusions:
- Age ≤65 years, presence of abdominal pain, and undergoing CRS plus adjuvant therapy are independent positive prognostic factors for MPM.
- These findings can inform treatment decisions and patient counseling for MPM.
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