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Updated: Apr 22, 2026
State of the Art Cranial Ultrasound Imaging in Neonates
Published on: February 2, 2015
Apert syndrome: temporal lobe abnormalities on fetal brain imaging
Zornitza Stark1, George McGillivray, Amanda Sampson
1Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, Australia; Fetal Medicine Unit, Royal Women's Hospital, Melbourne, Australia; Maternal Fetal Medicine, Sunshine Hospital, Western Health, Melbourne, Australia.
Objectives:
Apert syndrome is characterized by craniosynostosis and complex hand and foot syndactyly, and an increased risk of brain, palate, heart, and visceral malformations, and intellectual disability. This study aims to describe the structural brain abnormalities detected by dedicated neuroimaging of fetuses with Apert syndrome.
Methods:
Retrospective review of ultrasound and magnetic resonance imaging brain imaging obtained in six fetuses with a diagnosis of Apert syndrome.
Results:
Five fetuses had attenuation of the septal leaflets, and two had corpus callosum dysgenesis. All six had temporal lobe expansion and overconvolution and temporal lobe clefts. The temporal lobe abnormalities preceded the development of cranial deformity in two fetuses.
Conclusion:
Overexpansion and overconvolution of the temporal lobe is evident antenatally and is particularly conspicuous in the fetus when the normal brain is still relatively smooth (approximately 24 to 28 weeks of gestation).
