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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Published on: December 30, 2016
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Chemical shift separation with controlled aliasing for hyperpolarized (13) C metabolic imaging
Peter J Shin1,2, Peder E Z Larson1,2, Martin Uecker3
1Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, California, USA.
Magnetic Resonance in Medicine
|October 10, 2014
Summary
A new technique enables faster hyperpolarized Carbon-13 (¹³C) metabolic imaging by separating signals from multiple metabolites. This method achieves high-resolution images, improving metabolic analysis in medical research.
Area of Science:
- Magnetic Resonance Imaging
- Metabolic Imaging
- Spectroscopy
Background:
- Hyperpolarized Carbon-13 (¹³C) magnetic resonance imaging (MRI) offers metabolic insights.
- Current techniques face limitations in spatial and temporal resolution for simultaneous metabolite detection.
Purpose of the Study:
- Develop a chemical shift separation technique for high-resolution hyperpolarized ¹³C metabolic imaging.
- Enable simultaneous acquisition and separation of signals from multiple ¹³C metabolites.
Main Methods:
- Implemented a fast 3D pulse sequence with flyback echo-planar imaging readouts.
- Utilized multiband excitation radiofrequency pulses for spatial modulation.
- Applied a nonlinear inversion parallel imaging method for aliased image separation using an eight-channel coil array.
Main Results:
- Successfully acquired and separated simultaneous pyruvate and lactate signals in phantom and in vivo rat studies.
- Demonstrated high spatial resolution in the separated metabolite images.
- Validated the chemical shift separation technique for metabolic imaging.
Conclusions:
- The developed method accelerates metabolite imaging in hyperpolarized ¹³C MRI.
- Integration of multichannel coils, tailored readout, and specialized RF pulses is effective.
- This technique enhances the capability for detailed metabolic analysis using MRI.
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