Clinical aspects of urea transporters
Jianhua Ran1, Hongkai Wang, Tinghai Hu
1Department of Anatomy and Neuroscience Center, Basic Medical College, Chongqing Medical University, Yixueyuan Road 1, Chongqing, 400016, China, ranjianhua@cqmu.edu.cn.
Abstract:
Jk antigens, which were identified as urea transporter B (UT-B) in the plasma membrane of erythrocytes, and which determine the Kidd blood type in humans, are involved in transfusion medicine, and even in organ transplantation. The Jk(a-b-) blood type is a consequence of a silent Slc14A1 gene caused by various mutations related to lineage. In addition, the specific mutations related to hypertension and metabolic syndrome cannot be ignored. Genome-wide association studies established Slc14A1 as a related gene of bladder cancer and some genotypes are associated with higher morbidity. This chapter aims to introduce the clinical significance of urea transporters.
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